Details of the Drug

General Information of Drug (ID: DMKY8V1)

• Drug Name: Propiomazine
• Synonyms: Phenoctyl; Propiomazina; Propiomazinum; Propionylpromethazine; Dorevan (TN); Dorevane (TN); Indorm (TN); Largon (TN); Propavan (TN); Propiomazina [INN-Spanish]; Propiomazinum [INN-Latin]; Serentin (TN); Wy-1359; Propiomazine (USAN/INN); Propiomazine [USAN:BAN:INN]; Propiomazine [USAN:INN:BAN]; 1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone; 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one; 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one; 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine; 10-Dimethylaminoisopropyl-2-propionylphenothiazine; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; 3-Propionyl-10-dimethylaminoisopropylphenothiazine

Indication

Disease Entry	ICD 11	Status	REF
Insomnia	7A00-7A0Z	Approved	[1], [2], [3]

• Therapeutic Class: Sedatives and Hypnotics
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 340.5
  Topological Polar Surface Area (xlogp); 4.8
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 4
• ADMET Property:
  Metabolism: The drug is metabolized via the hepatic [4]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 2.44647 micromolar/kg/day [5]
• Chemical Identifiers:
  Formula: C20H24N2OS
  IUPAC Name: 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
  Canonical SMILES: CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C
  InChI: InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
  InChIKey: UVOIBTBFPOZKGP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 4940
  ChEBI ID: CHEBI:8491
  CAS Number: 362-29-8
  DrugBank ID: DB00777
  TTD ID: D0R9ZB

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[6]

Molecular Expression Atlas of This Drug

• The Studied Disease: Insomnia
• ICD Disease Classification: 7A00-7A0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Propiomazine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Propiomazine and ITI-007.	Insomnia [7A00-7A0Z]	[15]

Coadministration of a Drug Treating the Disease Different from Propiomazine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Oliceridine	DM6MDCF	Major	Additive CNS depression effects by the combination of Propiomazine and Oliceridine.	Acute pain [MG31]	[16]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[17]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[17]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Memantine.	Alzheimer disease [8A20]	[15]
Rivastigmine	DMG629M	Moderate	Antagonize the effect of Propiomazine when combined with Rivastigmine.	Alzheimer disease [8A20]	[18]
Donepezil	DMIYG7Z	Moderate	Antagonize the effect of Propiomazine when combined with Donepezil.	Alzheimer disease [8A20]	[18]
Isosorbide dinitrate	DMBI4JG	Moderate	Additive hypotensive effects by the combination of Propiomazine and Isosorbide dinitrate.	Anal fissure/fistula [DB50]	[19]
Amyl nitrite	DMJKO05	Moderate	Additive hypotensive effects by the combination of Propiomazine and Amyl nitrite.	Angina pectoris [BA40]	[19]
Nifedipine	DMSVOZT	Moderate	Additive hypotensive effects by the combination of Propiomazine and Nifedipine.	Angina pectoris [BA40]	[19]
Ephedrine	DMMV0KW	Moderate	Antagonize the effect of Propiomazine when combined with Ephedrine.	Asthma [CA23]	[20]
Lisdexamfetamine	DM6W8V5	Moderate	Antagonize the effect of Propiomazine when combined with Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[20]
Desipramine	DMT2FDC	Moderate	Increased plasma concentrations of Propiomazine and Desipramine due to competitive inhibition of the same metabolic pathway.	Attention deficit hyperactivity disorder [6A05]	[21]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Cariprazine.	Bipolar disorder [6A60]	[15]
Loperamide	DMOJZQ9	Moderate	Additive antimotility effects by the combination of Propiomazine and Loperamide.	Bowel habit change [ME05]	[22]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[23]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[23]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[23]
Dihydrocodeine	DMB0FWL	Major	Additive CNS depression effects by the combination of Propiomazine and Dihydrocodeine.	Chronic pain [MG30]	[16]
Propofol	DMB4OLE	Moderate	Additive cardiorespiratory depression effects by the combination of Propiomazine and Propofol.	Corneal disease [9A76-9A78]	[24]
Alfentanil	DMVO0UB	Major	Additive CNS depression effects by the combination of Propiomazine and Alfentanil.	Corneal disease [9A76-9A78]	[25]
Remifentanil	DMZTXCH	Major	Additive CNS depression effects by the combination of Propiomazine and Remifentanil.	Corneal disease [9A76-9A78]	[25]
Cyclobenzaprine	DM1YBRM	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[15]
Isocarboxazid	DMAF1NB	Moderate	Additive hypotensive effects by the combination of Propiomazine and Isocarboxazid.	Depression [6A70-6A7Z]	[26]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Propiomazine and OPC-34712.	Depression [6A70-6A7Z]	[15]
Phenelzine	DMHIDUE	Moderate	Additive hypotensive effects by the combination of Propiomazine and Phenelzine.	Depression [6A70-6A7Z]	[26]
Clomipramine	DMINRKW	Moderate	Increased plasma concentrations of Propiomazine and Clomipramine due to competitive inhibition of the same metabolic pathway.	Depression [6A70-6A7Z]	[21]
Doxepin	DMPI98T	Moderate	Increased plasma concentrations of Propiomazine and Doxepin due to competitive inhibition of the same metabolic pathway.	Depression [6A70-6A7Z]	[21]
Maprotiline	DMPWB7T	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Maprotiline.	Depression [6A70-6A7Z]	[15]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Propiomazine and Esketamine.	Depression [6A70-6A7Z]	[27]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Mepenzolate.	Digestive system disease [DE2Z]	[17]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Oxybutynine.	Discovery agent [N.A.]	[15]
Tetrabenazine	DMYWQ0O	Major	Increased risk of prolong QT interval by the combination of Propiomazine and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[28]
Deutetrabenazine	DMUPFLI	Major	Additive antidopaminergic effects by the combination of Propiomazine and Deutetrabenazine.	Dystonic disorder [8A02]	[29]
Zonisamide	DM0DTF7	Major	Increased risk of hyperpyrexia by the combination of Propiomazine and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[30]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[15]
Ethacrynic acid	DM60QMR	Moderate	Additive hypotensive effects by the combination of Propiomazine and Ethacrynic acid.	Essential hypertension [BA00]	[31]
Phenoxybenzamine	DM8KSQH	Moderate	Additive hypotensive effects by the combination of Propiomazine and Phenoxybenzamine.	Essential hypertension [BA00]	[19]
Nadolol	DMW6GVL	Moderate	Additive hypotensive effects by the combination of Propiomazine and Nadolol.	Essential hypertension [BA00]	[19]
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Solifenacin.	Functional bladder disorder [GC50]	[15]
Tolterodine	DMSHPW8	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Tolterodine.	Functional bladder disorder [GC50]	[15]
Terbinafine	DMI6HUW	Moderate	Decreased metabolism of Propiomazine caused by Terbinafine mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[32]
Propantheline	DM2EN6G	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Propantheline.	Gastric ulcer [DA60]	[15]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Propiomazine when combined with Pilocarpine.	Glaucoma [9C61]	[33]
Carvedilol	DMHTEAO	Moderate	Additive hypotensive effects by the combination of Propiomazine and Carvedilol.	Heart failure [BD10-BD1Z]	[19]
Chlorothiazide	DMLHESP	Moderate	Additive hypotensive effects by the combination of Propiomazine and Chlorothiazide.	Heart failure [BD10-BD1Z]	[19]
Bumetanide	DMRV7H0	Moderate	Additive hypotensive effects by the combination of Propiomazine and Bumetanide.	Heart failure [BD10-BD1Z]	[19]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Propiomazine and Procarbazine.	Hodgkin lymphoma [2B30]	[26]
Isosorbide mononitrate	DMYLMU0	Moderate	Additive hypotensive effects by the combination of Propiomazine and Isosorbide mononitrate.	Hydrocephalus [8D64]	[19]
Cinacalcet	DMCX0K3	Moderate	Decreased metabolism of Propiomazine caused by Cinacalcet mediated inhibition of CYP450 enzyme.	Hyper-parathyroidism [5A51]	[27]
Acebutolol	DM0TI4U	Moderate	Additive hypotensive effects by the combination of Propiomazine and Acebutolol.	Hypertension [BA00-BA04]	[19]
Captopril	DM458UM	Moderate	Additive hypotensive effects by the combination of Propiomazine and Captopril.	Hypertension [BA00-BA04]	[19]
Methyldopa	DM5I621	Moderate	Additive hypotensive effects by the combination of Propiomazine and Methyldopa.	Hypertension [BA00-BA04]	[19]
Nebivolol	DM7F1PA	Moderate	Additive hypotensive effects by the combination of Propiomazine and Nebivolol.	Hypertension [BA00-BA04]	[19]
Levamlodipine	DM92S6N	Moderate	Additive hypotensive effects by the combination of Propiomazine and Levamlodipine.	Hypertension [BA00-BA04]	[19]
TAK-491	DMCF6SX	Moderate	Additive hypotensive effects by the combination of Propiomazine and TAK-491.	Hypertension [BA00-BA04]	[19]
Pindolol	DMD2NV7	Moderate	Additive hypotensive effects by the combination of Propiomazine and Pindolol.	Hypertension [BA00-BA04]	[19]
Fenoldopam	DMFAOKP	Moderate	Additive hypotensive effects by the combination of Propiomazine and Fenoldopam.	Hypertension [BA00-BA04]	[19]
Indapamide	DMGN1PW	Moderate	Additive hypotensive effects by the combination of Propiomazine and Indapamide.	Hypertension [BA00-BA04]	[19]
Diazoxide	DML1538	Moderate	Additive hypotensive effects by the combination of Propiomazine and Diazoxide.	Hypertension [BA00-BA04]	[19]
Perindopril	DMOPZDT	Moderate	Additive hypotensive effects by the combination of Propiomazine and Perindopril.	Hypertension [BA00-BA04]	[19]
Quinapril	DMR8H31	Moderate	Additive hypotensive effects by the combination of Propiomazine and Quinapril.	Hypertension [BA00-BA04]	[19]
Telmisartan	DMS3GX2	Moderate	Additive hypotensive effects by the combination of Propiomazine and Telmisartan.	Hypertension [BA00-BA04]	[19]
Irbesartan	DMTP1DC	Moderate	Additive hypotensive effects by the combination of Propiomazine and Irbesartan.	Hypertension [BA00-BA04]	[19]
Hydralazine	DMU8JGH	Moderate	Additive hypotensive effects by the combination of Propiomazine and Hydralazine.	Hypertension [BA00-BA04]	[19]
Clevidipine butyrate	DMW4M97	Moderate	Additive hypotensive effects by the combination of Propiomazine and Clevidipine butyrate.	Hypertension [BA00-BA04]	[19]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[15]
Amantadine	DMS3YE9	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Amantadine.	Influenza [1E30-1E32]	[34]
Polyethylene glycol	DM4I1JP	Moderate	Increased risk of lowers seizure threshold by the combination of Propiomazine and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[35]
Dicyclomine	DMZSDGX	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Dicyclomine.	Irritable bowel syndrome [DD91]	[15]
Physostigmine	DM2N0TO	Moderate	Antagonize the effect of Propiomazine when combined with Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[18]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Propiomazine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[36]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Propiomazine and Lasmiditan.	Migraine [8A80]	[37]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Propiomazine and Flibanserin.	Mood disorder [6A60-6E23]	[38]
Thalidomide	DM70BU5	Moderate	Additive CNS depression effects by the combination of Propiomazine and Thalidomide.	Multiple myeloma [2A83]	[39]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Propiomazine and Ozanimod.	Multiple sclerosis [8A40]	[26]
Dextroamphetamine	DMMIHVP	Moderate	Antagonize the effect of Propiomazine when combined with Dextroamphetamine.	Narcolepsy [7A20]	[20]
Dimenhydrinate	DM264B3	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Dimenhydrinate.	Nausea/vomiting [MD90]	[15]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Promethazine.	Nausea/vomiting [MD90]	[15]
Metoclopramide	DMFA5MY	Major	Additive antidopaminergic effects by the combination of Propiomazine and Metoclopramide.	Nausea/vomiting [MD90]	[40]
Bupropion	DM5PCS7	Major	Decreased metabolism of Propiomazine caused by Bupropion mediated inhibition of CYP450 enzyme.	Nicotine use disorder [6C4A]	[41]
Phendimetrazine	DM6TS1N	Moderate	Antagonize the effect of Propiomazine when combined with Phendimetrazine.	Obesity [5B80-5B81]	[20]
Amfepramone	DM9YSNQ	Moderate	Antagonize the effect of Propiomazine when combined with Amfepramone.	Obesity [5B80-5B81]	[20]
Benzphetamine	DMIJATC	Moderate	Antagonize the effect of Propiomazine when combined with Benzphetamine.	Obesity [5B80-5B81]	[20]
Polythiazide	DMCH80F	Moderate	Additive hypotensive effects by the combination of Propiomazine and Polythiazide.	Oedema [MG29]	[31]
Lofexidine	DM1WXA6	Moderate	Additive hypotensive effects by the combination of Propiomazine and Lofexidine.	Opioid use disorder [6C43]	[19]
Apraclonidine	DMO4PVE	Moderate	Additive CNS depression effects by the combination of Propiomazine and Apraclonidine.	Optic nerve disorder [9C40]	[42]
Oxymorphone	DM65AGJ	Major	Additive CNS depression effects by the combination of Propiomazine and Oxymorphone.	Pain [MG30-MG3Z]	[25]
Levorphanol	DMGS80V	Major	Additive CNS depression effects by the combination of Propiomazine and Levorphanol.	Pain [MG30-MG3Z]	[25]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Flavoxate.	Pain [MG30-MG3Z]	[15]
Nalbuphine	DMOSQGU	Major	Additive CNS depression effects by the combination of Propiomazine and Nalbuphine.	Pain [MG30-MG3Z]	[25]
Methamphetamine	DMPM4SK	Moderate	Antagonize the effect of Propiomazine when combined with Methamphetamine.	Pain [MG30-MG3Z]	[43]
Buprenorphine	DMPRI8G	Major	Additive CNS depression effects by the combination of Propiomazine and Buprenorphine.	Pain [MG30-MG3Z]	[44]
Safinamide	DM0YWJC	Moderate	Additive hypotensive effects by the combination of Propiomazine and Safinamide.	Parkinsonism [8A00]	[26]
Pergolide	DM14MAE	Moderate	Antagonize the effect of Propiomazine when combined with Pergolide.	Parkinsonism [8A00]	[45]
Opicapone	DM1BKA6	Moderate	Antagonize the effect of Propiomazine when combined with Opicapone.	Parkinsonism [8A00]	[46]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Propiomazine and Rasagiline.	Parkinsonism [8A00]	[26]
Biperiden	DME78OA	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Biperiden.	Parkinsonism [8A00]	[17]
Levodopa	DMN3E57	Moderate	Antagonize the effect of Propiomazine when combined with Levodopa.	Parkinsonism [8A00]	[45]
Bromocriptine	DMVE3TK	Moderate	Antagonize the effect of Propiomazine when combined with Bromocriptine.	Parkinsonism [8A00]	[45]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Orphenadrine.	Parkinsonism [8A00]	[15]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Methylscopolamine.	Peptic ulcer [DA61]	[15]
ABIRATERONE	DM8V75C	Moderate	Decreased metabolism of Propiomazine caused by ABIRATERONE mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[47]
Terazosin	DM3JCVS	Moderate	Additive hypotensive effects by the combination of Propiomazine and Terazosin.	Prostate hyperplasia [GA90]	[19]
Silodosin	DMJSBT6	Moderate	Additive hypotensive effects by the combination of Propiomazine and Silodosin.	Prostate hyperplasia [GA90]	[19]
Neupro	DMHEAB1	Moderate	Antagonize the effect of Propiomazine when combined with Neupro.	Restless legs syndrome [7A80]	[45]
Quetiapine	DM1N62C	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Quetiapine.	Schizophrenia [6A20]	[15]
Mesoridazine	DM2ZGAN	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Mesoridazine.	Schizophrenia [6A20]	[17]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Aripiprazole.	Schizophrenia [6A20]	[15]
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Iloperidone.	Schizophrenia [6A20]	[15]
Perphenazine	DMA4MRX	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Perphenazine.	Schizophrenia [6A20]	[15]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Molindone.	Schizophrenia [6A20]	[15]
Thiothixene	DMDINC4	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Thiothixene.	Schizophrenia [6A20]	[15]
Trifluoperazine	DMKBYWI	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Trifluoperazine.	Schizophrenia [6A20]	[15]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Asenapine.	Schizophrenia [6A20]	[15]
Pimozide	DMW83TP	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Pimozide.	Schizophrenia [6A20]	[15]
Fentanyl	DM8WAHT	Major	Additive CNS depression effects by the combination of Propiomazine and Fentanyl.	Sensation disturbance [MB40]	[25]
Papaverine	DMCA9QP	Moderate	Additive hypotensive effects by the combination of Propiomazine and Papaverine.	Tonus and reflex abnormality [MB47]	[19]
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[15]
Brompheniramine	DMFOVSD	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Brompheniramine.	Vasomotor/allergic rhinitis [CA08]	[15]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Propiomazine and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[17]

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